Concepedia

WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA

Jiayi Wang, Jiehan Zhang, Yan Ma, Yuxiao Zeng, Cheng Lü, Fenghua Yang, Nianxin Jiang, Xuan Zhang, Yuhua Wang, Yinghui Xu,

Aging · 2021 · 127 citations · 17 references

DOIFull text

Open access

Concepts

Abstract

A modification of ATF4 mRNA. These findings highlight the importance of WTAP in I/R injury and provide new insights into therapeutic strategies for MI.

References

17

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

Xiaoli Ping, Baofa Sun, Lu Wang et al. · Cell Research · 2014 · 2.4K citations · Full text

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Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells

Krishna M. Vattem, Ronald C. Wek · Proceedings of the National Academy of Sciences · 2004 · 1.7K citations · Full text

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Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

Jaime D. Blais, Vasilisa Filipenko, Meixia Bi et al. · Molecular and Cellular Biology · 2004 · 444 citations · Full text

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Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia

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Ewald Dumont, Leo Hofstra, Waander L. van Heerde et al. · Circulation · 2000 · 176 citations

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