Concepedia

The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer

Zhongyuan Wang, Liang Zhou, Yejun Wang, Quanzhou Peng, Huan Li, Xin Zhang, Zijie Su, Jiaxing Song, Qi Sun, Sapna Sayed,

Theranostics · 2021 · 33 citations · 41 references

DOIFull text

Open access

Concepts

Abstract

Our results revealed that the CK1δ/ε-AES axis is important for CRC tumorigenesis and metastasis, and targeted inhibition of this axis may be a potential therapeutic strategy for CRC.

References

41

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF<sup>β-TRCP</sup>

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Rona Yaeger, Walid K. Chatila, Marla Lipsyc et al. · Cancer Cell · 2018 · 864 citations · Full text

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