Theranostics · 2021 · 103 citations · 36 references
Life SciencesNeurologyNeuroscienceInflammationMolecular NeurobiologyMolecular NeuroscienceAlzheimer DiseaseCognitive ImpairmentMicrorna BiologyNeurodegenerative DiseasesNeurodegenerative DisordersNeuroinflammationAlzheimer Disease NeuroprotectionMicroglial NeuroinflammationMicroglial PolarizationNeuritic PlaquesNeurodegenerative Disease MechanismsNeuroinflammation In Alzheimer DiseasePhagocytic ActivityTransgenic Mice
. Moreover, transcriptional analysis confirmed that miR-146a opposed the pathological process of AD mainly through neuroinflammation-related pathways. In summary, our results provide sufficient evidence for the mechanism by which miR-146a opposes AD and strengthen the conclusion that miR-146a is a promising target for AD and other microglia-related diseases.
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