Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

Udai Bhan Pandey, Zhiping Nie, Yakup Batlevi et al. · Nature · 2007 · 1.2K citations

Life Sciences, Cell Biology, Neuroscience +12

HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

Jeffrey J. Kovacs, Patrick J. Murphy, Stéphanie Gaillard et al. · Molecular Cell · 2005 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Stephen J. Haggarty, Kathryn M. Koeller, Jason Chun Yu Wong et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Oncology +12

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Kyle V. Butler, Jay H. Kalin, Camille Brochier et al. · Journal of the American Chemical Society · 2010 · 772 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Xiaohong Zhang, Zhigang Yuan, Yingtao Zhang et al. · Molecular Cell · 2007 · 725 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +4