Concepedia

Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

Pedro Mejia, J. Humberto Treviño-Villarreal, Mariana De Niz, Elamaran Meibalan, Alban Longchamp, Justin S. Reynolds, Lindsey B. Turnbull, Robert O. Opoka, Christian Roussilhon, Tobias Spielmann,

Science Advances · 2021 · 12 citations · 45 references

DOIFull text

Open access

Concepts

Abstract

infection did not increase circulating leptin levels, iRBC sequestration, tissue leptin production, and mTORC1 activity were positively correlated with CM in pediatric postmortem WAT. These data identify WAT sequestration as a trigger for leptin production with potential implications for pathogenesis of malaria infection, prognosis, and treatment.

References

45

European Guidelines for Obesity Management in Adults

Volkan Yumuk, Constantine Tsigos, Martin Fried et al. · Obesity Facts · 2015 · 3.4K citations · Full text

, , +8

Switches in expression of plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

Joseph D. Smith, Chetan E. Chitnis, David J. Roberts et al. · Cell · 1995 · 1K citations · Full text

, , +12

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Sarah H. Bates, Walter H. Stearns, Trevor A. Dundon et al. · Nature · 2003 · 1K citations

, , +11

Differentiating the pathologies of cerebral malaria by postmortem parasite counts

Terrie E. Taylor, Wenjiang J. Fu, Richard Carr et al. · Nature Medicine · 2004 · 729 citations

, , +14

Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum

A R Berendt, David L. Simmons, James Tansey et al. · Nature · 1989 · 701 citations

, , +16