Concepedia

Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin

Junjie Cheng, Yang Zhu, Xin Xing, Jianmin Xiao, Hui Chen, Hongwei Zhang, Dan Wang, Yuanyuan Zhang, Guilong Zhang, Zhengyan Wu,

Theranostics · 2021 · 114 citations · 26 references

DOIFull text

Open access

Concepts

Abstract

The Pt-FMO nanoplatform is designed to introduce mutual beneficial cascade reactions for promoting ferroptosis and apoptosis in combination with tumor MRI. The Pt-FMO system, which causes ferroptosis combined with apoptosis, can efficiently induce tumor cell death.

References

26

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Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv, Meixia Chen, Rui Zhang et al. · Cell Research · 2020 · 1K citations · Full text

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