Concepedia

Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload

Katherine A. Murphy, Brian Harsch, Chastity L. Healy, Sonal S. Joshi, Shue Huang, Rachel E. Walker, Brandon Wagner, Katherine M Ernste, Wei Huang, Robert Block,

Cardiovascular Research · 2021 · 34 citations · 32 references

DOIFull text

Open access

Abstract

Our data indicate that Ffar4 in cardiac myocytes responds to endogenous fatty acids, reducing oxidative injury, and protecting the heart from pathologic stress, with significant translational implications for targeting Ffar4 in cardiovascular disease.

References

32

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

Da Young Oh, Saswata Talukdar, Eun Ju Bae et al. · Cell · 2010 · 2.4K citations · Full text

, , +9

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Akira Hirasawa, Keiko Tsumaya, Takeo Awaji et al. · Nature Medicine · 2004 · 1.5K citations

, , +8

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

Makoto Arita, Francesca Bianchini, Júlio Aliberti et al. · The Journal of Experimental Medicine · 2005 · 903 citations · Full text

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Atsuhiko Ichimura, Akira Hirasawa, Odile Poulain‐Godefroy et al. · Nature · 2012 · 654 citations · Full text

, , +6

The regulation of adipogenesis through GPR120

Chizu Gotoh, Yeon-Hee Hong, Tomoyo Iga et al. · Biochemical and Biophysical Research Communications · 2007 · 242 citations

, , +8