Potential Therapeutic Effect of Bee Pollen and Metformin Combination on Testosterone and Estradiol Levels, Apoptotic Markers and Total Antioxidant Capacity in A Rat Model of Polycystic Ovary Syndrome.

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with metabolic disorder as well as infertility. Many traditional remedies have been reported to show estrogenic and antioxidant potential. Bee pollen is a natural compound, reported as one such remedy. The present study aimed to investigate the effects of BP extract and metformin (MET) on estradiol (E2) and testosterone (T) levels, apoptotic markers, and total antioxidant capacity (TAC) inarat model of PCOS. MATERIALS AND METHODS: genes were evaluated by real-time polymerase chain reaction (PCR). Data were statistically analyzed using one-way ANOVA. RESULTS: were increased in the BP- and MET-treated groups (P<0.05). CONCLUSION: BP and MET synergistically improved serum E2, T and TAC levels, and expression of apoptotic genes.