Concepedia

Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway

Wencui Wan, Wei Zhu, Yan Wu, Yang Long, Hongzhuo Liu, Weiwei Wan, Guangming Wan, Jing Yu

Journal of Inflammation Research · 2021 · 24 citations · 31 references

DOIFull text

Open access

Abstract

This study indicated that GSPE alleviated RPE cellular senescence through NAMPT/SIRT1/NLRP3 pathway. This study highlighted the potential effects of GSPE on degenerative retinopathy through the crosstalk of NAD+ metabolism, SIRT1 function and NLRP3 activation.

References

31

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

Malika Oubaha, Khalil Miloudi, Agnieszka Dejda et al. · Science Translational Medicine · 2016 · 253 citations

Mitochondrial DNA Damage and Repair in RPE Associated with Aging and Age-Related Macular Degeneration

Haijiang Lin, Haifeng Xu, Fong-Qi Liang et al. · Investigative Ophthalmology & Visual Science · 2011 · 156 citations · Full text

SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

Ying Han, Weiju Sun, Di Ren et al. · Redox Biology · 2020 · 126 citations · Full text

Metabolic signature of the aging eye in mice

Yekai Wang, Allison Grenell, Fanyi Zhong et al. · Neurobiology of Aging · 2018 · 91 citations

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Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro

Xiaxia Cai, Lei Bao, Jinwei Ren et al. · Food & Function · 2015 · 84 citations