Anti-cancer effect of metformin on the metastasis and invasion of primary breast cancer cells through mediating NF-kB activity

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Heather A. Hirsch, Dimitrios Iliopoulos, Philip N. Tsichlis et al. · Cancer Research · 2009 · 1.1K citations · Full text

Medicine, Oncology, Pharmacology +17

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

Harikrishna Nakshatri, Poornima Bhat‐Nakshatri, Daniel Martı́n et al. · Molecular and Cellular Biology · 1997 · 818 citations · Full text

Medicine, Molecular Biology, Oncology +16

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

Ralf C. Bargou, Florian Emmerich, Daniel Krappmann et al. · Journal of Clinical Investigation · 1997 · 765 citations · Full text

Medicine, Cell Biology, Oncology +15

Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation

Olga Moiseeva, Xavier Deschênes‐Simard, Emmanuelle St‐Germain et al. · Aging Cell · 2013 · 636 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

Gregory M. Helbig, Kent W. Christopherson, Poornima Bhat‐Nakshatri et al. · Journal of Biological Chemistry · 2003 · 635 citations · Full text

Medicine, Cell Biology, Oncology +14