Concepedia

Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: <i>In Vitro</i> Activity against SARS-CoV-2 and Potential Mechanisms

Ana C. Puhl, Ethan J. Fritch, Thomas R. Lane, Longping V. Tse, Boyd L. Yount, Carolina Q. Sacramento, Natalia Fintelman‐Rodrigues, Tatyana Almeida Tavella, Fábio Trindade Maranhão Costa, Stuart Weston,

ACS Omega · 2021 · 76 citations · 84 references

DOIFull text

Open access

Concepts

Abstract

observed in A549-ACE2 cells. We also provide novel insights into the mechanism of these compounds which is likely lysosomotropic.

References

84

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu, Dingyu Zhang, Xingwang Li et al. · New England Journal of Medicine · 2020 · 30.4K citations · Full text

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder et al. · Cell · 2020 · 21.4K citations · Full text

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A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

Linda Reed, Hugo Muench · American Journal of Epidemiology · 1938 · 20.2K citations

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp, Nianshuang Wang, Kizzmekia S. Corbett et al. · Science · 2020 · 9.8K citations · Full text

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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Alexander E. Gorbalenya, Susan C. Baker, Ralph S. Baric et al. · Nature Microbiology · 2020 · 7.7K citations · Full text

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