Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates

Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis

H.-G. Leser, Carmen Scheibenbogen, A. Heinisch et al. · Gastroenterology · 1991 · 354 citations · Full text

Veterinary Medicine, Immunology, Pathology +12

Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6

Marc Le Vée, Valérie Lecureur, Bruno Stieger et al. · Drug Metabolism and Disposition · 2008 · 259 citations

Medicine, Pharmacology, Toxicology +17

Disease–Drug–Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis

Christophe Schmitt, Bernd Kuhn, X Zhang et al. · Clinical Pharmacology & Therapeutics · 2011 · 251 citations

Medicine, Clinical Pharmacokinetics, Pharmacology +17

CYTOKINE LEVELS (IL-6 AND IFN-γ), ACUTE PHASE RESPONSE AND NUTRITIONAL STATUS AS PROGNOSTIC FACTORS IN LUNG CANCER

Fancisco Martı́n, Francisco Santolaria, Norberto Batista et al. · Cytokine · 1999 · 209 citations

Life Sciences, Immunology, Oncology +14

Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture

Leslie J. Dickmann, Sonal Patel, Dan A. Rock et al. · Drug Metabolism and Disposition · 2011 · 190 citations

Medicine, Pharmacology, Biochemical Pharmacology +16