Organic Letters · 2021 · 19 citations · 55 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryOrganometallic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisOrganic SynthesisAzetidine ChemistryEnantioselective SynthesisLactam SynthesisRegioselectivity In CycloadditionsStereoselectivity
The synthesis of γ-lactams is reported by a formal (3+2) cycloaddition between readily available ketenes and aziridines or a one-pot formal (2+1+2) cycloaddition using imines as aziridine precursors. The method is practical, is scalable, and affords high yields. It also offers a high level of regio- and diastereoselectivity on a wide range of substrates as well as a high stereoselectivity in the case of enantiopure aziridines.
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Total synthesis of (.+-.)-ginkgolide B
E.J. Corey, Myung-chol Kang, Manoj C. Desai et al. · Journal of the American Chemical Society · 1988 · 191 citations · Full text
Ya Du, Ying Wu, Anhua Liu et al. · The Journal of Organic Chemistry · 2008 · 170 citations