Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma

Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Claudia Allemani, Tomohiro Matsuda, V Di Carlo et al. · The Lancet · 2018 · 5.9K citations · Full text

Epidemiology, Cancer Epidemiology, Medicine +11

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev, Zhihong Huang, Michael Boyce et al. · Nature Chemical Biology · 2005 · 3K citations

Apoptosis, Cell Death, Pharmacotherapy +16

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Liming Sun, Huayi Wang, Zhigao Wang et al. · Cell · 2012 · 2.6K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Nils Holler, Rossana Zaru, Olivier Micheau et al. · Nature Immunology · 2000 · 1.9K citations

Kinase Rip, Signal Transduction, Signaling Pathway +11

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

Jixi Li, Thomas J. McQuade, Ansgar B. Siemer et al. · Cell · 2012 · 1.2K citations · Full text

Inflammation, Alzheimer's Disease, Cell Death +9