Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue

Anca Remes, Dima Ibrahim Basha, Thomas Puehler, Christopher Borowski, Susanne Hille, Laura Kummer, Andreas H. Wagner, Markus Hecker, Jasmin Soethoff, Georg Lutter,

Molecular Therapy — Methods & Clinical Development · 2021 · 30 citations · 35 references

DOIFull text

Open access

Concepts

Abstract

into AAV9SLR-containing hydrogel, and efficient transduction could be confirmed. These findings demonstrate that alginate hydrogel harboring a vascular-targeting AAV9SLR vector allows efficient local transduction of the aortic wall.

References

35