Concepedia

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective

Mona Seifert, Subhas Chandra Bera, Pauline van Nies, Robert N. Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M. Wood, Lawrence D. Harris,

2020 · 15 citations · 39 references

Open access

Abstract

We revise Remdesivir's mechanism of action and reveal SARS-CoV-2 ability to evade interferon-induced antiviral ddhCTP.

References

39

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Yan Gao, Liming Yan, Yucen Huang et al. · Science · 2020 · 1.7K citations · Full text

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Maria L. Agostini, Erica L. Andres, Amy Sims et al. · mBio · 2018 · 1.5K citations · Full text

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Calvin J. Gordon, Egor P. Tchesnokov, Emma Woolner et al. · Journal of Biological Chemistry · 2020 · 1K citations · Full text

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Robert N. Kirchdoerfer, Andrew B. Ward · Nature Communications · 2019 · 938 citations · Full text

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Calvin J. Gordon, Egor P. Tchesnokov, Joy Y. Feng et al. · Journal of Biological Chemistry · 2020 · 878 citations · Full text