Concepedia

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of <i>Mycobacterium tuberculosis</i> Growth

Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie V. Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss,

ACS Omega · 2021 · 33 citations · 27 references

DOIFull text

Open access

Concepts

Abstract

exposure remaining above the minimal inhibitory concentration for only a limited time.

References

27

Treatment of tuberculosis

Public Health · 1923 · 460 citations

, , +14

The WHO 2014 Global tuberculosis report—further to go

Alimuddin Zumla, Andrew J.T. George, Virendra K. Sharma et al. · The Lancet Global Health · 2014 · 447 citations · Full text

, , +9

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Anna E. Grzegorzewicz, Hà Phạm, Vijay A. K. B. Gundi et al. · Nature Chemical Biology · 2012 · 441 citations

, , +11

Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against <i>Mycobacterium tuberculosis</i> in a Series of In Vitro and In Vivo Models

Anne J. Lenaerts, Veronica Gruppo, Karen S. Marietta et al. · Antimicrobial Agents and Chemotherapy · 2005 · 305 citations

, , +14

Identification of Novel Inhibitors of <i>M. tuberculosis</i> Growth Using Whole Cell Based High-Throughput Screening

Sarah A. Stanley, Sarah Schmidt Grant, Tomohiko Kawate et al. · ACS Chemical Biology · 2012 · 253 citations

, , +13