D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

Life Sciences, Biochemistry, Molecular Biology +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

Mark S. Pearce, Jane A Salotti, Mark P. Little et al. · The Lancet · 2012 · 3.7K citations · Full text

Medicine, Oncology, Radiology +17

Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5—a population-based study

Gemma Gatta, Laura Botta, Silvia Rossi et al. · The Lancet Oncology · 2013 · 1.1K citations

Medicine, Oncology, Pediatrics +17