Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway - Concepedia

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Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway

DOI Full Paper Access

14

Citations

14

References

2021

Year

Ruxi Lv, Min Zhu, Kun Chen, Haitao Xie, Hongxia Bai, Qingfa Chen

The Scientific World JOURNAL

Abstract

Inhibition of FXR signaling with z-guggulsterone induced anticancer effects in SGC-7901 cells by decreasing cell proliferation and promoting apoptosis. Z-guggulsterone induced cell apoptosis through the mitochondria-dependent pathway.

References

	Year	Citations
Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype Ana Ferro, Bárbara Peleteiro, Matteo Malvezzi, European Journal of Cancer EpidemiologyCancer RiskCancer EpidemiologyGastrointestinal OncologyGastric Cancer Mortality	2014	615
Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1 Kwang Seok Ahn, Gautam Sethi, Bokyung Sung, Cancer Research Inducible Stat3 ActivationSignal TransducersImmunologyCell DeathInhibits Constitutive	2008	133
Guggulsterone-Induced Apoptosis in Human Prostate Cancer Cells Is Caused by Reactive Oxygen Intermediate–Dependent Activation of c-Jun NH2-Terminal Kinase Shivendra V. Singh, Sunga Choi, Yan Zeng, Cancer Research	2007	105
z-Guggulsterone, a constituent of Ayurvedic medicinal plant <i>Commiphora mukul</i>, inhibits angiogenesis <i>in vitro</i> and <i>in vivo</i> Dong Xiao, Shivendra V. Singh Molecular Cancer Therapeutics	2008	99
Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts Baoxiang Guan, Hao Li, Zhengduo Yang, Cancer	2012	97
Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion J. Y. Lee, Kyoungjae Lee, J. K. Lee, British Journal of Cancer Tumor BiologyPancreatic CancerMedicinePathologyCancer Cell Biology	2011	75
Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure Ismael Samudio, Marina Konopleva, Stephen Safe, Molecular Cancer Therapeutics Chemoprevention StrategyMitochondrial DysfunctionMixed-phenotype Acute LeukemiaApoptosisCell Death	2005	69
Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts Min An, Jae Hee Cheon, Seung Won Kim, Cancer Letters Tumor BiologyMedicineColon Cancer CellsPharmacologyColorectal Cancer	2009	67
Herb-Drug Interactions in Cancer Care. K. Simon Yeung, Jyothirmai Gubili, Jun J. Mao PubMed Medicinal MushroomDrug InteractionsChemoprevention StrategyMedicineAlternative Medicine	2018	54
Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells Jae Hee Cheon Oncology Reports	1994	51

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