Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts

Abstract

Inhibition of FXR by FXR shRNA or guggulsterone suppressed tumor cell viability and induced apoptosis in vitro, and it reduced tumor formation and growth in nude mouse xenografts. FXR also mediated bile acid-induced alterations of cell growth-related genes in esophageal cancer cells.