Concepedia

Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome

Xinyu Yang, Ning Zhan, Yang Jin, Hanzhi Ling, Chipeng Xiao, Zhen Xie, Hao Zhong, Xinxin Yu, Jinglan Ma, Ju-Bo Guan,

Theranostics · 2020 · 60 citations · 32 references

DOIFull text

Open access

Concepts

Abstract

Recovery of γδTreg/γδT17 cell balance was a novel mechanism by which TOF alleviated RA. Meanwhile, NLRP3 played a pivotal role in the process of TOF-mediated γδT17 cell activation.

References

32

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

William J. Sandborn, Chinyu Su, Bruce E. Sands et al. · New England Journal of Medicine · 2017 · 1.7K citations · Full text

, , +14

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt, Kelly Kersten, Chris W. Doornebal et al. · Nature · 2015 · 1.7K citations · Full text

, , +14

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

Keiji Hirota, Hiroyuki Yoshitomi, Motomu Hashimoto et al. · The Journal of Experimental Medicine · 2007 · 924 citations · Full text

, , +13

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

Eun Bong Lee, Roy Fleischmann, Stephen Hall et al. · New England Journal of Medicine · 2014 · 774 citations · Full text

, , +13

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Hexin Shi, Ying Wang, Xiaohong Li et al. · Nature Immunology · 2015 · 737 citations

, , +15