Filters in Dissolution Testing: Evaluation and Selection

Abstract

Filtration is critical in drug dissolution testing as filtration stops the dissolution process and allows for accurate quantitation through separation of dissolved and un-dissolved components. Filtration is one of the simplest sample preparation techniques. Regardless, little attention is paid to filter selection, and that can negatively impact the quantitation of dissolved active pharmaceutical ingredients. This review provides information on various characteristics of membranes and filter devices to help researchers make an educated decision on filter selection during the method development and validation phases.