Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

Abstract

The intergenic region of <i>CACNA2D3</i> and <i>WNT5A</i> was revealed as a novel locus for asthma exacerbations despite ICS treatment in European populations. Genes associated were related to trichostatin A, suggesting that this drug could regulate the molecular mechanisms involved in treatment response.