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The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization

Medicinal ChemistrySar OptimizationCovalent InhibitorPharmaceutical ScienceBiochemistryPharmaceutical ResearchMedicineNatural SciencesRational Drug DesignPharmacotherapyDrug DevelopmentPharmacologyPharmaceutical ChemistryDrug DiscoveryIc50 Determination