<i>Campylobacter jejuni</i> Cytolethal Distending Toxin Causes a G ₂ -Phase Cell Cycle Block

Chris A. Whitehouse, Paul Balbo, Everett C. Pesci, +3

Infection and Immunity

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Jean‐Baptiste Telliez, Martin E. Dowty, Lu Wang, +33

ACS Chemical Biology

Jak1 InhibitionImmunologyImmune RegulationInnate ImmunityInflammatory Arthritis +28

Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation

Robert D. Perry, Paul Balbo, Heather Jones, +2

Microbiology

EngineeringBacteriologyMolecular BiologyMaximal ExpressionYersinia Pestis +14

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker, +24

Journal of Medicinal Chemistry

Specific InhibitorDrug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +23

Mechanism of Poly(A) Polymerase: Structure of the Enzyme-MgATP-RNA Ternary Complex and Kinetic Analysis

Paul Balbo, Andrew Bohm

Structure

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

Agustin Casimiro‐Garcia, John I. Trujillo, F.F. Vajdos, +18

Journal of Medicinal Chemistry

Medicinal ChemistryCovalent InhibitorsPharmaceutical ChemistryBiochemistrySelective Jak3 Inhibitors +10

The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization

Atli Thorarensen, Paul Balbo, Mary Ellen Banker, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistrySar OptimizationCovalent InhibitorPharmaceutical ScienceBiochemistry +10

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Shenping Liu, Leslie Dakin, Xing Li, +25

Scientific Reports

Structure of Yeast Poly(A) Polymerase in Complex with a Peptide from Fip1, an Intrinsically Disordered Protein

Gretchen Meinke, Chukwudi Ezeokonkwo, Paul Balbo, +3

Biochemistry

X-ray Crystallographic and Steady State Fluorescence Characterization of the Protein Dynamics of Yeast Polyadenylate Polymerase

Paul Balbo, Joe Toth, Andrew Bohm

Journal of Molecular Biology

Yeast Polyadenylate PolymeraseProtein X-ray CrystallographyMolecular BiologyProtein DynamicsStructural Biology +4