Concepedia

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

Katja Stefan, Lionel Leck, Vigneshwaran Namasivayam, Pablo Bascuñana, Michael Huang, Patrick J. Riss, Jens Pahnke, Patric J. Jansson, Sven Marcel Stefan

Future Drug Discovery · 2020 · 17 citations · 50 references

DOIFull text

Open access

Concepts

Abstract

besides ABC transporters themselves, the vesicles in which they reside, the lipid raft microdomains in which they are organized and oligomerized as well as the cytoskeleton are new potential drug targets.

References

50

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Deposition of Alzheimer's ??-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

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Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

Junkang Xu, Yang Liu, Youyun Yang et al. · Journal of Biological Chemistry · 2004 · 268 citations · Full text

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