Endoplasmic reticulum stress aggravates copper-induced apoptosis via the PERK/ATF4/CHOP signaling pathway in duck renal tubular epithelial cells

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 619 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Histopathological effects of waterborne copper nanoparticles and copper sulphate on the organs of rainbow trout (Oncorhynchus mykiss)

Genan A. Al-Bairuty, Benjamin J. Shaw, Richard D. Handy et al. · Aquatic Toxicology · 2012 · 269 citations

Veterinary Medicine, Environmental Sciences, Toxicology +13

Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways

Abhijit Sarkar, Joydeep Das, Prasenjit Manna et al. · Toxicology · 2011 · 166 citations

Medicine, Cell Biology, Nephrology +12

Water contamination with heavy metals and trace elements from Kilembe copper mine and tailing sites in Western Uganda; implications for domestic water quality

Mwesigye R. Abraham, Susan Balaba Tumwebaze · Chemosphere · 2016 · 154 citations

Natural Sciences, Environmental Sciences, Mining Engineering +17

Molybdenum and cadmium co-induce oxidative stress and apoptosis through mitochondria-mediated pathway in duck renal tubular epithelial cells

Gaohui Nie, Fan Yang, Jian Chen et al. · Journal of Hazardous Materials · 2019 · 128 citations

Pharmacy, Cell Biology, Toxicology +16