Ellagic Acid Inhibits <i>Trichophyton rubrum</i> Growth via Affecting Ergosterol Biosynthesis and Apoptotic Induction

Abstract

Overall, our results revealed the underlying antifungal mechanism of EA and SK, which may be related to the destruction of the fungal cell membrane and inhibition of C14 demethylase and the catalytic rate of squalene cyclooxidase in the ergosterol biosynthesis pathway via downregulation of MEP4 and SUB1, suggesting that EA and SK have the potential to be developed further as a natural antifungal agent for clinical use.