Late‐stage Pd‐catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media

Abstract

Abstract New technology is described that enables late stage ppm Pd‐catalyzed cyanations of highly complex molecules, as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a commercially available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent.