Concepedia

New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study

Sin‐Min Li, Shuo‐En Tsai, Chia‐Yin Chiang, Cheng‐Yen Chung, Tsung-Jui Chuang, Ching‐Chun Tseng, Wen‐Ping Jiang, Guan‐Jhong Huang, Chin‐Yu Lin, Ya–Chen Yang,

Bioorganic Chemistry · 2020 · 52 citations · 27 references

DOI

Concepts

References

27

Fluorine substituent effects (on bioactivity)

Bruce E. Smart · Journal of Fluorine Chemistry · 2001 · 1.5K citations

, , +4

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1<i>H</i>-pyrazolo[3,4-<i>c</i>]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Stephanie C. Koch et al. · Journal of Medicinal Chemistry · 2007 · 397 citations · Full text

, , +14

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Jane L. Wang, David C. Limburg, Matthew J. Graneto et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 335 citations · Full text

, , +15

Anti-inflammatory and side effects of cyclooxygenase inhibitors.

Halis Süleyman, Berna Demircan, Yalçın Karagöz · PubMed · 2008 · 317 citations

, , +14

LigRMSD: a web server for automatic structure matching and RMSD calculations among identical and similar compounds in protein-ligand docking

José Luís Velázquez‐Libera, Fabio Durán-Verdugo, Alejandro Valdés-Jiménez et al. · Bioinformatics · 2020 · 178 citations · Full text

, , +12