Kinetics of the heparin-enhanced antithrombin III/thrombin reaction. Evidence for a template model for the mechanism of action of heparin.

Abstract

Heparin-enhanced Antithrombin III/Thrombin ReactionHj' is heparin not bound to antithrombin 111.Substituting Equations 5 and 6 into Equation 2, Equation 1 can be rewritten to describe the rate of thrombin inhibition in terms of T, AT, and H,.'The derivations and theoretical data for the heparin-thrombin and heparin-antithrombin 111 models are available upon request.