Stability liabilities of biotherapeutic proteins: Early assessment as mitigation strategy

The focusing positions of polypeptides in immobilized pH gradients can be predicted from their amino acid sequences

Bengt Bjellqvist, Graham J. Hughes, Christian Pasquali et al. · Electrophoresis · 1993 · 1K citations

The Thermal Stability of Immunoglobulin: Unfolding and Aggregation of a Multi-Domain Protein

Arnoldus W. P. Vermeer, Willem Norde · Biophysical Journal · 2000 · 661 citations · Full text

Protein Chemistry, Multi-domain Protein, Protein Assembly +8

Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution

Jun Liu, Mary D.H. Nguyen, James D. Andya et al. · Journal of Pharmaceutical Sciences · 2005 · 433 citations

Concentrated Monoclonal Antibody, Aqueous Solution, Glycobiology +8

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

Brian D. Connolly, Chris Petry, Sandeep Yadav et al. · Biophysical Journal · 2012 · 328 citations · Full text

Diffusion Interaction Parameter, Engineering, Immunocytochemical Technique +13

Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies

Alexandre Goyon, Mélissa Excoffier, Marie-Claire Janin-Bussat et al. · Journal of Chromatography B · 2017 · 208 citations

Isoelectric Points, Immunocytochemical Technique, Biochemistry +11