Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · Animals · 2014 · 713 citations · Full text

Medicine, Biomedical Sciences, Epidemiology +12

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

MarkS. Gold, D. Eugene Redmond, H D Kleber · The Lancet · 1978 · 709 citations

Medicine, Pharmacology, Pharmacotherapy +12

Self‐treatment of opioid withdrawal using kratom (<i>Mitragynia speciosa korth</i>)

Edward W. Boyer, Kavita M. Babu, Jessica E. Adkins et al. · Addiction · 2008 · 345 citations

Medicine, Pharmacology, Toxicology +17

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

András Váradi, Gina F. Marrone, Travis C. Palmer et al. · Journal of Medicinal Chemistry · 2016 · 320 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12