Coniferyl Aldehyde Inhibits the Inflammatory Effects of Leptomeningeal Cells by Suppressing the JAK2 Signaling

Abstract

This study demonstrates that activated macrophages by <i>P. gingivalis</i> markedly induce the release of proinflammatory cytokines (TNF-<i>α</i>, IL-1<i>β</i>, and IL-6) from leptomeningeal cells, thereby activating the JAK2 signaling pathway and subsequently enhancing immune responses in microglia in the CNS. CA effectively inhibits the inflammatory effect of leptomeningeal cells via suppressing the JAK2 signaling pathway.