Concepedia

CSRP2 suppresses colorectal cancer progression <i>via</i> p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways

Lixia Chen, Xiaoli Long, Shiyu Duan, Xunhua Liu, Jian‐Xiong Chen, Jiawen Lan, Xuming Liu, Wen-Qing Huang, Jian Geng, Jun Zhou

Theranostics · 2020 · 63 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

Our results suggest that the CSRP2/p130Cas/Rac1 axis can inhibit CRC aggressiveness and metastasis through the Hippo, ERK, and PAK signaling pathways. Therefore, CSRP2 may be a potential therapeutic target for CRC.

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