Concepedia

Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis

Haiou Yang, Haiyang Zhang, Yuchong Yang, Xinyi Wang, Ting Deng, Rui Liu, Tao Ning, Ming Bai, Hongli Li, Kegan Zhu,

Theranostics · 2020 · 209 citations · 15 references

DOIFull text

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Concepts

Abstract

Hypoxia-derived exosomal circ-133 transported into normaxic cancer cells and promoted cell migration via miR-133a/GEF-H1/RhoA axis. This study reveals a potential mechanism for that the intra-tumor heterogeneity of oxygen promote cancer progression.

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