Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Sibylle Jäger, Christoph Handschin, Julie St‐Pierre et al. · Proceedings of the National Academy of Sciences · 2007 · 2.4K citations · Full text

Muscle Function, Direct Phosphorylation, Metabolic Remodeling +21

A highly reproducible rotenone model of Parkinson's disease

Jason R. Cannon, Vı́ctor Tapias, Hye Mee Na et al. · Neurobiology of Disease · 2009 · 774 citations · Full text

Parkinson Disease, Neurochemical Biomarkers, Neurology +4

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

Daniel Meley, Chantal Bauvy, Judith H.P.M. Houben-Weerts et al. · Journal of Biological Chemistry · 2006 · 452 citations · Full text

Mitophagy, Ampk Activity, Immunology +19

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

Giuseppa Mudò, Johanna Mäkelä, Valentina Di Liberto et al. · Cellular and Molecular Life Sciences · 2011 · 295 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Transgenic Expression +10

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

Giuseppe Filomeni, Ilaria Graziani, Daniela De Zio et al. · Neurobiology of Aging · 2010 · 258 citations

Rotenone-mediated Acute Toxicity, Cell Autophagy, Mitophagy +12