Concepedia

Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

Rajesh T. Gandhi, Joshua C. Cyktor, Ronald J. Bosch, Hanna Mar, Gregory M. Laird, Albine Martin, Ann C. Collier, Sharon A. Riddler, Bernard Macatangay, Charles R. Rinaldo,

The Journal of Infectious Diseases · 2020 · 142 citations · 26 references

DOIFull text

Open access

Abstract

Cells containing intact, replication-competent proviruses are selectively lost during suppressive ART. Defining the mechanisms involved should inform strategies to accelerate HIV-1 reservoir depletion.

References

26

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Diana Finzi, Joel N. Blankson, Janet D. Siliciano et al. · Nature Medicine · 1999 · 2.1K citations

, , +12

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Janet D. Siliciano, Joleen Kajdas, Diana Finzi et al. · Nature Medicine · 2003 · 1.7K citations

, , +8

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

Ya‐Chi Ho, Liang Shan, Nina N. Hosmane et al. · Cell · 2013 · 1.4K citations · Full text

, , +9

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Frank Maldarelli, Xiaolin Wu, Li Su et al. · Science · 2014 · 877 citations · Full text

Defective proviruses rapidly accumulate during acute HIV-1 infection

Katherine M. Bruner, Alexandra J. Murray, Ross A. Pollack et al. · Nature Medicine · 2016 · 747 citations · Full text

, , +6