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Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate

Jayaprakasam Bolleddula, Abhi Shah, Mohammad Shadid, Afrand Kamali, Michael D. Smith, Swapan K. Chowdhury

Drug Metabolism and Disposition · 2020 · 10 citations · 8 references

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8

The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates

Hans K. Erickson, Gail D. Lewis Phillips, Douglas D. Leipold et al. · Molecular Cancer Therapeutics · 2012 · 195 citations

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Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin

Dhaval K. Shah, Nahor Haddish‐Berhane, Alison Betts · Journal of Pharmacokinetics and Pharmacodynamics · 2012 · 156 citations

, , +15

Drug Delivery in Cancer Therapy, Quo Vadis?

Zheng‐Rong Lu, Peter Qiao · Molecular Pharmaceutics · 2018 · 102 citations

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A New Class of Antibody–Drug Conjugates with Potent DNA Alkylating Activity

Michael L. Miller, Nathan Fishkin, Wěi Li et al. · Molecular Cancer Therapeutics · 2016 · 101 citations

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Phase I Study of the Investigational Anti-Guanylyl Cyclase Antibody–Drug Conjugate TAK-264 (MLN0264) in Adult Patients with Advanced Gastrointestinal Malignancies

Khaldoun Almhanna, Thea Kalebic, Cristina Cruz et al. · Clinical Cancer Research · 2016 · 45 citations · Full text

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