Novel phenyl and thiophene dispiro indenoquinoxaline pyrrolidine quinolones induced apoptosis <i>via</i> G1/S and G2/M phase cell cycle arrest in MCF-7 cells

Abstract

New phenyl and thiophene dispiro indeno quinoxaline pyrrolidine quinolone analogues were synthesized by a one-pot four-component [3+2] cycloaddition reaction between (<italic>E</italic>)-3-arylidene-2,3-dihydro-8-nitro-4-quinolones, <italic>o</italic>-phenylenediamine, ninhydrin, and benzylamine/thiophenemethylamine.