Concepedia

Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis

Hongxia Tang, Chaoqun Li, Yue Zhang, Hongyue Zheng, Ying Cheng, Jingjing Zhu, Xiaojie Chen, Zhihong Zhu, Ji‐Gang Piao, Fanzhu Li

Theranostics · 2020 · 132 citations · 28 references

DOIFull text

Open access

Concepts

Abstract

Such a GSH-starvation therapeutic strategy would cause multi-path programmed cell death and could be a promising strategy for cancer therapy.

References

28

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Ferroptosis as a p53-mediated activity during tumour suppression

Le Jiang, Ning Kon, Tongyuan Li et al. · Nature · 2015 · 3.4K citations · Full text

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RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Nicholas Yagoda, Moritz von Rechenberg, Elma Zaganjor et al. · Nature · 2007 · 1.6K citations · Full text

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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Alexander Seiler, Manuela Schneider, Heidi Förster et al. · Cell Metabolism · 2008 · 1.4K citations · Full text

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The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses

Qianjun He, Jiamin Zhang, Jianlin Shi et al. · Biomaterials · 2009 · 499 citations

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