Concepedia

Genetic modifiers of long‐term survival in sickle cell anemia

Ambroise Wonkam, Emile R. Chimusa, Khuthala Mnika, Gift D. Pule, Valentina Josiane Ngo Bitoungui, Nicola Mulder, Daniel Shriner, Charles N. Rotimi, Adebowale Adeyemo

Clinical and Translational Medicine · 2020 · 35 citations · 31 references

DOIFull text

Open access

Abstract

This study provides new gene sets that contribute to variability in clinical expression of SCA. Identified genes and pathways suggest new avenues for other interventions.

References

31

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Aaron McKenna, Matthew G. Hanna, Eric Banks et al. · Genome Research · 2010 · 28.9K citations · Full text

Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death

Orah S. Platt, Donald Brambilla, Wendell F. Rosse et al. · New England Journal of Medicine · 1994 · 3.3K citations · Full text

The Genetic Structure and History of Africans and African Americans

Sarah A. Tishkoff, Floyd A. Reed, Françoise R. Friedlaender et al. · Science · 2009 · 1.5K citations · Full text

, , +25

Global Burden of Sickle Cell Anaemia in Children under Five, 2010–2050: Modelling Based on Demographics, Excess Mortality, and Interventions

Frédéric B. Piel, Simon I Hay, Sunetra Gupta et al. · PLoS Medicine · 2013 · 1.1K citations · Full text

Sickle Cell Disease in Africa

Scott D. Grosse, Isaac Odame, Hani K. Atrash et al. · American Journal of Preventive Medicine · 2011 · 668 citations · Full text

, , +25