Concepedia

HI-511 overcomes melanoma drug resistance <i>via</i> targeting AURKB and BRAF V600E

Xiaoyu Chang, Tianshun Zhang, Qiushi Wang, Moeez Rathore, Kanamata Reddy, Hanyong Chen, Seung Ho Shin, Wei-Ya Ma, Ann M. Bode, Zigang Dong

Theranostics · 2020 · 27 citations · 40 references

DOIFull text

Open access

Concepts

Abstract

AURKB is a potential target for melanoma treatment. HI-511, a novel dual-target inhibitor against both AURKB and BRAF V600E, could achieve durable suppression of melanoma growth, even drug-resistant melanoma growth.

References

40

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Zefang Tang, Chenwei Li, Chenwei Li et al. · Nucleic Acids Research · 2017 · 10.6K citations · Full text

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