Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes

Abstract

APOL1 is found in the ER and plasma membrane, consistent with either the ER stress or surface cation channel models of APOL1-mediated cytotoxicity. The surface localization of APOL1 variants potentially opens new therapeutic targeting avenues.

References

Page 1

	Year	Citations
Fiji: an open-source platform for biological-image analysis Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise, Nature Methods BiologyBiological-image AnalysisImage AnalysisEngineeringMicroscope Image Processing	2012	67.6K
Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca <sup>2+</sup> Responses Rosario Rizzuto, Paolo Pinton, Walter Carrington, Science	1998	2.2K
Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans Giulio Genovese, David J. Friedman, Michael D. Ross, Science GlomerulonephritisUrologyRenal FunctionKidney ResearchMedicine	2010	2K
A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression Moin A. Saleem, Michael J. O’Hare, Jochen Reiser, Journal of the American Society of Nephrology Cell PhysiologyProtein FunctionDevelopmental BiologySignal TransductionCell Regulation	2002	1.1K
PROTEIN IMPORT INTO MITOCHONDRIA Walter Neupert Annual Review of Biochemistry Tom ComplexBiochemistryMitochondrial FunctionProtein FoldingMedicine	1997	1K
Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells Mariusz R. Wiȩckowski, Carlotta Giorgi, Magdalena Lebiedzińska, Nature Protocols Membrane FusionBiochemistryMitochondrial FunctionOrganelle DynamicPhysiology	2009	935
Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene Shay Tzur, Saharon Rosset, Revital Shemer, Human Genetics	2010	633
The Substantial Loss of Nephrons in Healthy Human Kidneys with Aging John C. Lieske, Harini A. Chakkera, Emilio D. Poggio, Journal of the American Society of Nephrology Glomerular DiseaseRenal PathologyNephron NumberGlomerulonephritisRenal Function	2016	417
Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions Tilman Schlothauer, Sylvia Herter, Claudia Ferrara, Protein Engineering Design and Selection ImmunologyImmune RegulationImmunodominanceImmunologic MechanismImmunotherapeutics	2016	388
Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1 Brendan Nichols, Prachi Jog, Jessica H. Lee, Kidney International InflammationGlomerulonephritisAutoimmune DiseaseMedicineLupus Nephritis	2014	347

Page 1