Spatio‐Temporally Reporting Dose‐Dependent Chemotherapy via Uniting Dual‐Modal MRI/NIR Imaging

Abstract

Abstract Unpredictable in vivo therapeutic feedback of hydroxyl radical ( . OH) efficiency is the major bottleneck of chemodynamic therapy. Herein, we describe novel Fenton‐based nanotheranostics NQ‐Cy@Fe&GOD for spatio‐temporally reporting intratumor . OH‐mediated treatment, which innovatively unites dual‐channel near‐infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces the dose distribution of Fenton‐based iron oxide nanoparticles (IONPs) with high‐spatial resolution, meanwhile timely fluorescence signal quantifies . OH‐mediated therapeutic response with high spatio‐temporal resolution. NQ‐Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and . OH‐induced NQO1 enzyme in living cells and tumor‐bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio‐temporally reporting chemodynamic therapy, so as to manipulate dose‐dependent therapeutic process.