Concepedia

Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease

Jérémy Ortillon, Nathalie Hézard, Karim Belmokhtar, Charlotte Kawecki, Christine Terryn, G. Fritz, Alexandre Kauskot, Ann Marie Schmidt, Philippe Rieu, Philippe Nguyên,

Thrombosis and Haemostasis · 2020 · 11 citations · 34 references

DOI

Abstract

Our results show that CKD induces platelet hyperactivation, accelerates thrombus formation in a murine model of arterial thrombosis, and that RAGE deletion has a protective role. We propose that RAGE ligands binding to RAGE is involved in CKD-induced arterial thrombosis.

References

34

Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization

Alan S. Go, Glenn M. Chertow, Dongjie Fan et al. · New England Journal of Medicine · 2004 · 11.2K citations · Full text

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

Ann Marie Schmidt, Shi Du Yan, Shi Fang Yan et al. · Journal of Clinical Investigation · 2001 · 1K citations · Full text

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

A.M. Schmidt, Osamu Hori, J X Chen et al. · Journal of Clinical Investigation · 1995 · 893 citations · Full text

, , +19

<i>N</i><sup>ε</sup>-(Carboxymethyl)lysine Protein Adduct Is a Major Immunological Epitope in Proteins Modified with Advanced Glycation End Products of the Maillard Reaction

Kazuyoshi Ikeda, Takayuki Higashi, Hiroyuki Sano et al. · Biochemistry · 1996 · 430 citations

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

Evis Harja, De-xiu Bu, Barry I. Hudson et al. · Journal of Clinical Investigation · 2008 · 362 citations · Full text