PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation

Lauren Foltz, Juan Palacios‐Moreno, Makenzie E Mayfield, Shelby Kinch, Jordan Dillon, Jed T. Syrenne, Tyler Levy, Mark L. Grimes

Molecular Biology of the Cell · 2020 · 12 citations · 43 references

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Abstract

Different receptor tyrosine kinases employ shared downstream cell signaling pathways to induce differentiation or proliferation. The scaffold protein, PAG1 controls SRC-family kinase (SFK) activity in lipid rafts, and new data show that PAG1 also influences SFK sequestration in multivesicular bodies and is required for neuronal differentiation.

References

43