Concepedia

Chemerin Reactivates PTEN and Suppresses PD-L1 in Tumor Cells via Modulation of a Novel CMKLR1-mediated Signaling Cascade

Keith Rennier, Woo Jae Shin, Ethan Krug, Gurpal Virdi, Russell K. Pachynski

Clinical Cancer Research · 2020 · 66 citations · 47 references

DOI

Abstract

Collectively, our data show a novel link between chemerin, PTEN, and PD-L1 in human tumor lines, which may have a role in improving T-cell-mediated immunotherapies.

References

47

Integrative Clinical Genomics of Advanced Prostate Cancer

Dan R. Robinson, Eliezer M. Van Allen, Yi-Mi Wu et al. · Cell · 2015 · 3.6K citations · Full text

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Comprehensive analyses of tumor immunity: implications for cancer immunotherapy

Bo Li, Eric A. Severson, Jean‐Christophe Pignon et al. · Genome biology · 2016 · 2.7K citations · Full text

Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Weiyi Peng, Jie Qing Chen, Chengwen Liu et al. · Cancer Discovery · 2015 · 1.5K citations · Full text

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

Andrew T. Parsa, James S. Waldron, Amith Panner et al. · Nature Medicine · 2006 · 1.3K citations

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Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids

Valérie Wittamer, Jean‐Denis Franssen, Marisa Vulcano et al. · The Journal of Experimental Medicine · 2003 · 870 citations · Full text

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