A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent

Lentivirus-delivered stable gene silencing by RNAi in primary cells

Sheila A. Stewart, Derek M. Dykxhoorn, Deborah Palliser et al. · RNA · 2003 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Protein-binding assays in biological liquids using microscale thermophoresis

Christoph J. Wienken, Philipp Baaske, Ulrich Rothbauer et al. · Nature Communications · 2010 · 1.1K citations · Full text

Natural Sciences, Biochemistry, Biophysics +12

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

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Life Sciences, Chemical Biology, Molecular Biology +13

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Marco Jost, Yuwen Chen, Luke A. Gilbert et al. · Molecular Cell · 2017 · 274 citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (<i>E</i>)-2-{2-Methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure–Activity Relationship, and Biological Activity

M. V. Ramana Reddy, Muralidhar R. Mallireddigari, Venkat R. Pallela et al. · Journal of Medicinal Chemistry · 2011 · 95 citations · Full text

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