Modulating lipid and glucose metabolism by glycosylated kaempferol rich roasted leaves of Lycium chinense via upregulating adiponectin and AMPK activation in obese mice-induced type 2 diabetes

Abstract

The aim of the study was to elucidate the protective action of roasted Lycium chinense (rLF) enhanced kaempferol glycosides as bioactive components from obese-induced type 2 diabetes mice by investigating the histopathological, biochemical, and transcriptional analyses in blood, liver, and adipose tissue. The rLF extract significantly decreased the hypertrophy of fat deposition, pancreatic hyperplasia, hyperinsulinemia, hepatocellular steatosis, and nephropathy in a dose dependent manner (p < 0.01). However, rLF increased the expression of adiponectin while decreased leptin and sterol response element-binding protein 1c (SREBP1c) expression. rLF also upregulated the expression of AMP-activated protein kinase α1 (AMPKα1) and AMPKα2. The results from this study suggested that rLF extract could be an effective ingredient to prevent obese-induced type 2 diabetes damages by enhancing both adiponectin-induced signaling and AMPK activity in the liver.